Traffic can be heavy. Allow extra time, particularly in the summer and on weekends.
From New York City:
Via I-95 North; about 255 miles; approximately 4.5 hours, 4.25 hours without traffic. Take I-95 N, I-195 E, MA-25 E and US-6 E to MA-132 S/Iyannough Rd in Barnstable. Take exit 6 from US-6 E; Follow MA-132 S/Iyannough Rd and Bearses Way to North St in Hyannis; follow signs to airport or ferry docks.
Via I-495 South; about 275 miles; approximately 4.75 hours, 4.5 hours without traffic. Take I-95 N, follow signs for Connecticut 8 N/Connecticut 15 N/Shelton/Waterbury, CT-15 N, I-91 N, I-84 E/E Hartford/Boston, exit onto I-90 E toward Boston/N.H. – Maine, I-495 S toward Cape Cod, MA-25 E, I-495 S and MA-25 E to Blue Star Memorial Highway in Bourne; Take Sandwich Road to US-6 E; Follow US-6 E to MA-132 S/Iyannough Road in Barnstable. Take exit 6 from US-6 E; Follow MA-132 S/Iyannough Road and Bearses Way to North Street in Hyannis; follow signs to airport or ferry docks.
Via I-84 E; about 285 miles; approximately 5.25 hours, 4.5 hours without traffic. Take I-87 N, I-684 N, I-84 E/E Hartford/Boston, exit onto I-90 E toward Boston/N.H. – Maine, I-495 S toward Cape Cod, MA-25 E, I-495 S and MA-25 E to Blue Star Memorial Highway in Bourne; Take Sandwich Road to US-6 E; Follow US-6 E to MA-132 S/Iyannough Road in Barnstable. Take exit 6 from US-6 E; Follow MA-132 S/Iyannough Road and Bearses Way to North Street in Hyannis; follow signs to airport or ferry docks.
From Boston:
Via I-495 South; about 85 miles; approximately 1.75 hours, 1.5 hours without traffic. I-93 S. Take MA-24 S, I-495 S and MA-25 E to Blue Star Memorial Highway in Bourne; Take Sandwich Road to US-6 E; Follow US-6 E to MA-132 S/Iyannough Road in Barnstable. Take exit 6 from US-6 E; Follow MA-132 S/Iyannough Road and Bearses Way to North Street in Hyannis; follow signs to airport or ferry docks.
Via MA-3 South; about 70 miles; approximately 2 hours, 1.25 hours without traffic.I-93 S, MA-3 S and US-6 E to MA-132 S/Iyannough Road in Barnstable. Take exit 6 from US-6 E; Follow MA-132 S/Iyannough Road and Bearses Way to North Street in Hyannis; follow signs to airport or ferry docks.
By Bus
Service between Hyannis and Boston South Station or Logan Airport; Approximately 2 hours without traffic. Allow extra time, particularly in the summer and on weekends.